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Publishes complete research papers in all areas of mutation research which focus on fundamental mechanisms underlying phenotypic and genotypic expression of genetic damage, molecular mechanisms of mutagenesis including the relationship between genetic damage and its manifestation as hereditary diseases and cancers as well as aging.

Publishes complete papers in the field of genetic toxicology, focusing on genotoxicity testing of specific chemical or physical agents, in silico, in vitro, or in vivo; the isolation and chemical characterization of novel environmental mutagens; the measurement of genotoxic effects in human populations, particularly in the context of well-characterized environmental or occupational exposures; the development, evaluation, validation, and improvement of assay systems; and the assessment of health risks resulting from genotoxic exposures.

Publishes reviews on the relationship between mutation and disease, technologies for mutation detection and functional genomics, molecular mechanisms of mutagenesis, clinical genetics, genetic toxicology, and health risk assessment. The "Reflections" feature publishes reviews of historically important events in the field of mutagenesis and updating such events to the present to see what impact that event has had on current science.